A clinical review of antibody-mediated pure red cell aplasia.

Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by severe anemia from selectivefailure of the bone marrow to produce mature red blood cells. This disorder can be congenital or acquired from various causes. The development of PRCA in patients with chronic kidney disease receiving recombinant erythropoietin (rHuEPO) for renal anemia has increased in recent years. This review will enable nurses to recognize the pathogenesis, clinical manifestations, and therapeutic options for rHuEPO-induced PRCA.