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Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line.

Weiying Gu, Zixing Chen, Shaoyan Hu, Huiling Shen, Guoqiang Qiu, Xiangshan Cao
Haematologica 2005 March
The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.

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