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Changes in expression of WT1 isoforms during induced differentiation of the NB4 cell line

Weiying Gu, Zixing Chen, Shaoyan Hu, Huiling Shen, Guoqiang Qiu, Xiangshan Cao
Haematologica 2005, 90 (3): 403-5
15749674
The levels of expression of WT1 gene and WT1+17AA isoforms rapidly decreased during the differentiation of NB4 cells induced by all-trans retinoic acid; this decrease was conversely related to the dynamic changes of CD11b positive cells, indicating that the abnormally high expression of WT1 gene and WT1+17AA isoforms was associated with a block of NB4 cell differentiation.

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