JOURNAL ARTICLE

[Protective effects of total flavones of metasequosia on cerebral ischemia-reperfusion injury in rats]

Fang Wang, En-xin Yu, Wei-wan Liu
Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica 2004, 29 (2): 179-81
15719691

OBJECTIVE: To observe the protective effects of total flavones of metasequosia (TFM) on cerebral ischemia-reperfusion injury in rats.

METHOD: The bilateral vertebral arteries of rats were occluded under anesthesia, and 4-5 h later the carotid arteries of rats in the conscious condition were occluded for 30 min followed by reperfusion for 90 min. The effects of TFM on the contents of water, Na+, Ca2+ in cortex, malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in brain hemispheres, as well as the EEG activities were observed.

RESULT: After 30 min ischemia and 90 min reperfusion, the contents of water, Na+ , Ca2+ and MDA were increased, and the SOD activity was reduced with abnormal EEG activity and ischemic injury in the brain tissues. TFM 25-100 mg x kg(-1) ip 30 min before the carotid arteries were occluded, decreased the elevated water, Na+, Ca2+ and MDA contents, increased the SOD activity, reduced the ischemic injury of brain tissue, and promoted the recovery of EEG activities.

CONCLUSION: TFM has a protective effect on cerebral ischemia-reperfusion injury in rats.

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