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A case of disseminated Langerhans' cell histiocytosis treated with thalidomide.

E Mauro, C Fraulini, G M Rigolin, R Galeotti, R Spanedda, G Castoldi
European Journal of Haematology 2005 Februrary
Tumor necrosis factor alpha (TNF-alpha) seems to play a key role in the pathogenesis of Langerhans' cell histiocytosis (LCH). Thalidomide is an immunomodulator agent of inflammatory cytokines including TNF-alpha. To our knowledge this is the first case of disseminated LCH successfully treated with thalidomide.

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