OPEN IN READ APP
JOURNAL ARTICLE
REVIEW

[Genetic predisposition and ovarian cancer]

Isabelle Coupier, Marion Gauthier-Villars, Pascale This, Dominique Stoppa-Lyonnet
La Revue du Praticien 2004 October 31, 54 (16): 1757-62
15630879
The genetic predisposition to epithelial ovarian cancer can be distinguished in two different forms: familial breast and/or ovarian cancer; familial colon, endometrium, ovarian cancer or HNPCC syndrome (hereditary non polyposis colorectal cancer). The BRCA1 and BRCA2 genes are involved in familial breast and (or) ovarian cancer. Mutations of these two genes could explain 5.5% (2-7%) of ovarian cancers. The hMLH1, hMSH2, and hMSH6 genes are involved in the HNPCC syndrome. The mutations of these genes could explain 1% to 2% of ovarian cancers. The clinical management of women at ovarian cancer risk is variable and dependent on the predisposition going from regular examination until prophylactic oophorectomy in the presence of BRCA mutations.

Comments

You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Trending on Read

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
15630879
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"