Efficacy of low and high 131I doses for thyroid remnant ablation in patients with differentiated thyroid carcinoma based on post-operative cervical uptake

Pedro W S Rosário, Janice S Reis, Alvaro L Barroso, Leonardo L Rezende, Eduardo L Padrão, Tales A Fagundes
Nuclear Medicine Communications 2004, 25 (11): 1077-81

OBJECTIVE: The aim of this study was to determine the efficacy of low (1110 MBq (30 mCi)) and high (3700 MBq (100 mCi)) 131I doses on the ablation of post-surgical remnants in patients with thyroid cancer based on the measurement of post-operative cervical uptake.

METHODS: The study was conducted on 155 patients without metastases after thyroidectomy who received a 1110 or 3700 MBq ablative dose and who were assessed by pre-therapy cervical uptake. The patients were divided into six groups according to the uptake result and the dose received. Successful therapy was defined as a negative scan 6 months to 1 year after ablation.

RESULTS: Ablative therapy was successful in 90% of patients with uptake <2% who received the 1110 MBq dose (n=30) and in 92.5% of patients who received the 3700 MBq dose (n=40), P=0.95. In the group with uptakes ranging from 2% to 5%, successful therapy was observed in 65% of patients receiving 1110 MBq (n=20) and in 86.6% of patients receiving 3700 MBq (n=30), P=0.14. In patients with uptake >5%, a 46.6% success rate was obtained for the 1110 MBq dose (n=15), while efficacy was 70% in patients receiving 3700 MBq (n=20), P=0.16.

CONCLUSION: This study demonstrated the efficacy of low doses in patients with lower remnants after surgery (uptake <2%), the inverse correlation between uptake and ablation efficacy with low and high doses, and the usefulness of the measurement of cervical uptake for the definition of the ablative 131I dose.

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