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CASE REPORTS
JOURNAL ARTICLE
Therapy of refractory pemphigus vulgaris with monoclonal anti-CD20 antibody (rituximab).
Journal of the American Academy of Dermatology 2004 November
Three patients with refractory pemphigus vulgaris improved after rituximab, an anti-CD20 monoclonal antibody directed against B cells. Treatment was well tolerated immediately, but one patient developed fatal pneumocystis carinii pneumonia. Serious infections have occurred in several pemphigus patients treated with rituximab and immunosuppressive medications, warranting further evaluation of risk-benefit ratio.
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