Introduction of the American/Asian genotype of dengue 2 virus into the Yucatan State of Mexico

María A Loroño-Pino, José A Farfán-Ale, Alicia L Zapata-Peraza, Elsy P Rosado-Paredes, Luis F Flores-Flores, Julián E García-Rejón, Francisco J Díaz, Bradley J Blitvich, Manuel Andrade-Narváez, Eusebio Jiménez-Ríos, Carol D Blair, Ken E Olson, William Black, Barry J Beaty
American Journal of Tropical Medicine and Hygiene 2004, 71 (4): 485-92
A dengue (DEN) outbreak occurred in the Yucatan State of Mexico in 2002. Three isolates were obtained from patients presenting with DEN-like symptoms, and examined by partial nucleotide sequencing and phylogenetic analysis. The isolates were identified as DEN-2 viruses of the American-Asian genotype; this is the first report of this genotype in the Yucatan State. The DEN-2 viruses of the American-Asian genotype have been associated with more severe disease outcomes. Thus, its introduction into the Yucatan State presents a serious problem to public health authorities. During this outbreak, DEN virus infection was confirmed in 18% (282 of 1,560) of the patients who presented with DEN-like symptoms. Of these, 87 (31%) patients met the World Health Organization criteria for dengue hemorrhagic fever, including two patients who died. The majority (77%) of the patients experienced secondary infections in this epidemic.

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