We have located links that may give you full text access.
Cross-validation for linear model with unequal variances in genomic analysis.
Journal of Biopharmaceutical Statistics 2004 August
In recent years, genomic studies are usually conducted to identify genes that may have an impact on clinical outcomes. The identified genes are then used to establish a predictive model for identifying subjects who are most likely to respond to the test treatment in clinical trials. This information is useful in early and later phases of clinical development. The United States Food and Drug Administration (FDA) requires that such a predictive model be validated before it can be used in clinical development. Shao [Shao, J. (1993). Linear model selection by cross-validation. J. Amer. Statist. Assoc. 88(422):486-494] proposed a cross-validation method for linear model with equal variances, which is found useful in genomic studies. In practice, however, genomic data may be obtained from different sources with unequal variances. As a result, Shao's method may not be applied directly. In this paper, we extend Shao's method for cross-validation of a linear model with unequal variances. Along this line, two re-sampling methods were proposed to account for the heterogeneity in variance. Several simulations were performed to evaluate the finite samples performances of the proposed methods. An example concerning a breast cancer research is present to illustrate the use of the proposed methods.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
2024 ACC Expert Consensus Decision Pathway for Treatment of Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee.Journal of the American College of Cardiology 2024 March 3
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis.Critical Care Medicine 2024 Februrary 8
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app