Reversible neurotoxicity after an overdose of topical lindane in an infant

Lindane (gamma benzene hexachloride) is a widely prescribed topical scabicide because of its efficacy and cost-effectiveness. Although toxicity from a single proper application of lindane is generally not observed, the hazards of repeated applications, industrial exposure, and accidental ingestion have been well documented. We herein describe an infant with reversible neurotoxicity following repeated applications of 1% lindane for the treatment of scabies. The role of factors predisposing to increased absorption and the recommendations to minimize potential neurotoxicity are emphasized.