The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism

E Virginia Armbrust, John A Berges, Chris Bowler, Beverley R Green, Diego Martinez, Nicholas H Putnam, Shiguo Zhou, Andrew E Allen, Kirk E Apt, Michael Bechner, Mark A Brzezinski, Balbir K Chaal, Anthony Chiovitti, Aubrey K Davis, Mark S Demarest, J Chris Detter, Tijana Glavina, David Goodstein, Masood Z Hadi, Uffe Hellsten, Mark Hildebrand, Bethany D Jenkins, Jerzy Jurka, Vladimir V Kapitonov, Nils Kröger, Winnie W Y Lau, Todd W Lane, Frank W Larimer, J Casey Lippmeier, Susan Lucas, Mónica Medina, Anton Montsant, Miroslav Obornik, Micaela Schnitzler Parker, Brian Palenik, Gregory J Pazour, Paul M Richardson, Tatiana A Rynearson, Mak A Saito, David C Schwartz, Kimberlee Thamatrakoln, Klaus Valentin, Assaf Vardi, Frances P Wilkerson, Daniel S Rokhsar
Science 2004 October 1, 306 (5693): 79-86
Diatoms are unicellular algae with plastids acquired by secondary endosymbiosis. They are responsible for approximately 20% of global carbon fixation. We report the 34 million-base pair draft nuclear genome of the marine diatom Thalassiosira pseudonana and its 129 thousand-base pair plastid and 44 thousand-base pair mitochondrial genomes. Sequence and optical restriction mapping revealed 24 diploid nuclear chromosomes. We identified novel genes for silicic acid transport and formation of silica-based cell walls, high-affinity iron uptake, biosynthetic enzymes for several types of polyunsaturated fatty acids, use of a range of nitrogenous compounds, and a complete urea cycle, all attributes that allow diatoms to prosper in aquatic environments.

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