[Collagen synthesis and expression of connective tissue growth factor in the cultured fibroblasts of human hypertrophic scar]

Shi-rong Li, Jian-yi Liu, Shu-xing Ji
Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery 2004, 20 (2): 124-7

OBJECTIVE: To explore the effect of connective tissue growth factor on the pathogenesis of human hypertrophic scar.

METHODS: Normal skin and hypertrophic scar fibroblasts were cultured in vitro. The collagen synthesis of fibroblasts were measured by H3-proline incorporation method. The expression of connective tissue growth factor protein and mRNA of fibroblasts were detected with immunocytochemistry staining and reverse transcription polymerase chain reaction methods.

RESULTS: Compared with normal skin fibroblast, the collagen synthesis and the expression of connective tissue growth factor protein and mRNA in the hypertrophic scar fibroblast was higher (P < 0.01).

CONCLUSION: Connective tissue growth factor may play an important role in promoting the fibrotic process of hypertrophic scar.

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