JOURNAL ARTICLE
REVIEW

New developments in ochronosis: review of the literature

Julie M Keller, William Macaulay, Ohannes A Nercessian, Israeli A Jaffe
Rheumatology International 2005, 25 (2): 81-5
15322814
Ochronosis commonly affects all connective tissue. Recognition of changes secondary to the deposition of ochronotic pigments has increased with advances in diagnostic technology, allowing both improved imaging and early biochemical and genetics-based diagnosis of alkaptonuria, the cause of ochronosis. Successful symptomatic treatment of ochronotic arthropathy with joint replacement has been documented, and a new pharmacotherapeutic agent, nitisinone, is currently under investigation for both prevention and treatment of ochronosis. This review of the literature highlights recently recognized complications, new diagnostic techniques, and treatment options.

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