Antibody detection tests for Onchocerca volvulus: comparison of the sensitivity of a cocktail of recombinant antigens used in the indirect enzyme-linked immunosorbent assay with a rapid-format antibody card test

Mario A Rodríguez-Pérez, Alfredo Domínguez-Vázquez, Jorge Méndez-Galván, Ana M Sifuentes-Rincón, Patricia Larralde-Corona, Hugo A Barrera-Saldaña, Janette E Bradley
Transactions of the Royal Society of Tropical Medicine and Hygiene 2003, 97 (5): 539-41
There is a need for a specific, sensitive, and practical diagnostic test to monitor onchocerciasis elimination campaigns. In April 2001, an enzyme-linked immunosorbent assay (ELISA) using 3 recombinant antigens and a rapid-format antibody card test (immunochromatographic test; ICT) using an individual antigen were compared in a Mexican population with onchocerciasis. The sensitivity of the ELISA and ICT was 97% and 86%, respectively.

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