JOURNAL ARTICLE

Feasibility of HLA-haploidentical hematopoietic stem cell transplantation between noninherited maternal antigen (NIMA)-mismatched family members linked with long-term fetomaternal microchimerism

Tatsuo Ichinohe, Takashi Uchiyama, Chihiro Shimazaki, Keitaro Matsuo, Shigehisa Tamaki, Masayuki Hino, Arata Watanabe, Motohiro Hamaguchi, Souichi Adachi, Hisashi Gondo, Nobuhiko Uoshima, Takao Yoshihara, Kazuo Hatanaka, Hiroshi Fujii, Keisei Kawa, Kazunobu Kawanishi, Koji Oka, Hideo Kimura, Mitsuru Itoh, Takeshi Inukai, Etsuko Maruya, Hiroh Saji, Yoshihisa Kodera
Blood 2004 December 1, 104 (12): 3821-8
15280193
Based on the hypothesis that long-term fetomaternal microchimerism is associated with acquired immunologic hyporesponsiveness to noninherited maternal antigens (NIMAs) or inherited paternal antigens (IPAs), several groups have recently reported successful cases of non-T-cell-depleted hematopoietic stem cell transplantation (SCT) from HLA-haploidentical family members mismatched for NIMAs. In this study, we examined the outcomes of 35 patients with advanced hematologic malignancies who underwent HLA-2-antigen- or HLA-3-antigen-incompatible SCT from a microchimeric NIMA-mismatched donor. After standard-intensity or reduced-intensity preparative regimens, all patients had sustained hematopoietic recovery with tacrolimus-based graft-versus-host disease (GVHD) prophylaxis. Grade II/IV acute GVHD occurred in 19 (56%) of 34 evaluable patients, while extensive chronic GVHD developed in 13 (57%) of 23 patients who could be evaluated. Multivariate analysis demonstrated that NIMA mismatch in the GVH direction was associated with a lower risk of severe grade III-IV acute GVHD when compared with IPA mismatch (P = .03). Fifteen patients were alive and 14 of them were disease-free with a median follow-up of 20 (range, 8 to 37) months. These results indicate that T cell-replete SCT from an HLA-haploidentical NIMA-mismatched donor can offer durable remission with an acceptable risk of GVHD in selected patients with advanced hematologic malignancies who lack immediate access to a conventional stem cell source.

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