60-minute application of S-Caine Peel prior to 1,064 nm long-pulsed Nd:YAG laser treatment of leg veins

Ming H Jih, Paul M Friedman, Neil Sadick, Denise K Marquez, Arash Kimyai-Asadi, Leonard H Goldberg
Lasers in Surgery and Medicine 2004, 34 (5): 446-50

BACKGROUND AND OBJECTIVES: Advancements in laser treatment of leg veins necessitate concurrent investigations in topical anesthesia to minimize treatment-related pain. To evaluate the efficacy of the S-Caine Peel for providing topical anesthesia after a 60-minute application.

STUDY DESIGN/PATIENTS AND METHODS: A randomized, double-blinded, placebo-controlled trial was performed in two centers. Sixty patients received S-Caine Peel and placebo vehicle on different treatment sites for 60 minutes prior to laser treatment of leg veins using a 1,064 nm long-pulsed Nd:YAG laser. Patients rated their level of pain using a visual analog scale. Adequacy of anesthesia and expressed pain at each site were rated by the investigator.

RESULTS: The mean visual analog scale (VAS) was 27 mm for active sites compared to 43 mm for placebo (P < 0.001). Improved pain relief was noted for 67% of active versus 30% of placebo sites (P < 0.001). Anesthesia was judged adequate by the investigator for 55% of active compared with 12% of placebo sites (P < 0.001).

CONCLUSIONS: The S-Caine Peel is safe and effective when applied for 60 minutes prior to laser therapy of leg veins.

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