Treatment of nocturnal leg cramps. A crossover trial of quinine vs vitamin E

P S Connolly, E A Shirley, J H Wasson, D W Nierenberg
Archives of Internal Medicine 1992, 152 (9): 1877-80

OBJECTIVE: This study compared the efficacy and safety of quinine sulfate, vitamin E, and placebo in the treatment of nocturnal leg cramps.

DESIGN: A random-order, double-blind, placebo-controlled crossover trial was performed.

SETTING: The study was conducted at the Veterans Affairs Medical Center, White River Junction, Vt.

PARTICIPANTS: Twenty-seven male veterans, aged 38 to 73 years, who experienced at least six leg cramps per month were recruited through the general medicine walk-in clinic or were referred from other clinics. Fifty-five subjects were contacted, 30 were enrolled consecutively, and 27 completed the study.

INTERVENTION: Subjects received, in random order, quinine sulfate (200 mg at supper and 300 mg at bedtime), vitamin E (800 U at bedtime), or placebo for 4-week periods. These periods were separated by 4-week washout intervals.

OUTCOME MEASURES: Patients reported cramp frequency, severity, and sleep disturbance caused by cramps.

RESULTS: Compared with treatment with placebo, quinine reduced the frequency of cramps and sleep disturbance, but not the average cramp severity. Thirteen of 27 patients had at least a 50% reduction in the number of cramps while receiving quinine; the response was usually seen within 3 days. There was evidence of a mild increase in side effects while subjects received quinine. Vitamin E was not effective in reducing leg cramp frequency, severity, or sleep disturbance.

CONCLUSIONS: Quinine sulfate, but not vitamin E, is superior to placebo in the treatment of nocturnal leg cramps.

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