Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
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A randomised study comparing systemic transdermal treatment and local application of glyceryl trinitrate ointment in the management of chronic anal fissure.

OBJECTIVE: To compare a systemic transdermal therapeutic system with local application of glyceryl trinitrate ointment in the treatment of anal fissure.

DESIGN: Prospective, multicentre, randomised trial.

SETTING: Three teaching hospitals, Turkey.

SUBJECTS: 89 outpatients with chronic anal fissure were randomly assigned to be treated with either transdermal (n = 52) or 0.2% glyceryl trinitrate ointment (n = 37).

INTERVENTIONS: The patients were assessed at the sixth and the twelfth week after initial evaluation by physical examination, anoscopy, and anal manometry.

MAIN OUTCOME MEASURES: Changes in the maximal anal resting pressure, healing rate.

RESULTS: Anal fissure was completely healed in 38 (73%) and 24 (64%) of the patients after 6 weeks and 48 (81%) and 27 (79%) of the patients in transdermal group and ointment group, respectively. Maximal anal resting pressure was reduced by 24% and 21% in transdermal and ointment groups, respectively.

CONCLUSION: Systemic transdermal application of glyceryl trinitrate gave a satisfactory healing rate, which was comparable to that of local application of ointment.

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