JOURNAL ARTICLE

[Preparation and the anti-tumor activity of mutant Staphylococcal enterotoxin B]

Xiao-hong Deng, Yu-ling Zheng, Feng Yu, Bao-an Ning, Yong-qiang Jiang
Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology 2004, 20 (3): 360-2
15193239

AIM: To prepare mutant Staphylococcal enterotoxin B(SEB) and observe its anti-tumor activity.

METHODS: The expressed mutant SEB-K172E in inclusion body was denatured and renatured, and then isolated and purified. The anti-tumor activity of the mutant SEB-K172E was compared with wild-type SEB.

RESULTS: Renaturation and purification method of the mutant SEB-K172E was developed. The anti-tumor activity of acquired mutant protein was ten times higher than that of wild-type SEB.

CONCLUSION: The anti-tumor activity of the mutant SEB-K172E is much higher than that of wild-type SEB, suggesting that the mutant SEB-K172E may become a potential anti-tumor drug.

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