JOURNAL ARTICLE

[Study on therapeutic window of opportunity for Panax notoginseng saponins following focal cerebral ischemia/reperfusion injury in rats]

Wei He, Zunping Zhu, Jianxin Liu, Heyang Ye, Jin Zeng, Xianhua Huang, Fei Lai
Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials 2004, 27 (1): 25-7
15179785

OBJECTIVE: To study the therapeutic window of opportunity for Panax notoginseng saponins (Pns) following focal cerebral ischemia/reperfusion injury in rats.

METHODS: Focal cerebral ischemia (2 h)/reperfusion (24 h) model in male rats was induced by transient occlusion and middle cerebral artery (MCA) for 2 h and reperfusion for 24 h. Drugs were administered at 3 h, 4 h, 5 h and 6 h after the onset of ischemia respectively and neurological deficit score, infarct size and brain edema were examined.

RESULTS: The administration of Pns at 3-4 h after onset of ischemia significantly reduced neurological deficit score, infarct size and brain edema. When administrating Pns at 5 h after onset of ischemia, the neuroprotection decreased. When administrating Pns at 6 h after onset of ischemia, there are not significant protective effects.

CONCLUSION: The therapeutic window of opportunity for Pns following focal cerebral ischemia/reperfusion injury in rats is not more than 5 h after the onset of ischemia.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
15179785
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"