Dapsone hypersensitivity syndrome masquerading as a viral exanthem: three cases and a mini-review.

INTRODUCTION: We report 3 cases of dapsone hypersensitivity syndrome due to anti-malarial chemoprophylactic treatment with maloprim, in military servicemen, presenting like a viral exanthem.

CLINICAL PICTURE: Three male military recruits presented with fever and rash, 6 to 8 weeks after commencing on weekly doses of maloprim.

TREATMENT: A course of topical and systemic corticosteroids and oral antihistamines were started.

OUTCOME: All cases showed gradual resolution of fever, rash and eventual normalisation of liver function test.

CONCLUSION: A high index of suspicion was required before this uncommon syndrome can be recognised. Early institution of corticosteroid therapy and discontinuation of maloprim are the mainstays of treatment.