CLINICAL TRIAL
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RANDOMIZED CONTROLLED TRIAL
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Simvastatin reduces interleukin-1beta secretion by peripheral blood mononuclear cells in patients with essential hypertension.

BACKGROUND: Chronic low-grade inflammation may contribute to the increased risk of atherosclerosis in essential hypertension. Statins have been reported to have anti-inflammatory effects. We studied whether individuals with essential hypertension have increased interleukin-1beta (IL-1beta) secretion in peripheral blood mononuclear cells (PBMCs) and whether treatment with simvastatin lowered IL-1beta secretion by PBMCs.

METHODS: PBMCs were isolated by gradient centrifugation from 24 individuals with essential hypertension (EH) and 12 normotensive subjects. The IL-1beta concentrations in the supernatant from PBMCs were measured by enzyme-linked immunosorbent assay (ELISA). The patients with EH were then randomized to treatment with valsartan 80 mg/day or matching group who took the same drug valsartan 80 mg/day plus simvastatin 40 mg/day for 1 week. IL-1beta secretion by PBMCs was also measured.

RESULTS: Compared with controls, patients with EH had increased IL-1beta [992+/-151 pg/ml, 912+/-102 pg/ml vs. 599+/-93 pg/ml; P<0.05] secretion by PBMCs after stimulated by angiotensin II. Simvastatin treatment had a significant effect of decreasing IL-1beta [668+/-98 vs. 923+/-67 pg/ml; P<0.05] secretion in PBMCs. The reductions were not correlated to changes in plasma lipids.

CONCLUSIONS: This study shows that EH is associated with increased PBMCs activation and that treatment with simvastatin may partly attenuate this abnormality.

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