Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D

Motomichi Matsuzaki, Osami Misumi, Tadasu Shin-I, Shinichiro Maruyama, Manabu Takahara, Shin-Ya Miyagishima, Toshiyuki Mori, Keiji Nishida, Fumi Yagisawa, Keishin Nishida, Yamato Yoshida, Yoshiki Nishimura, Shunsuke Nakao, Tamaki Kobayashi, Yu Momoyama, Tetsuya Higashiyama, Ayumi Minoda, Masako Sano, Hisayo Nomoto, Kazuko Oishi, Hiroko Hayashi, Fumiko Ohta, Satoko Nishizaka, Shinobu Haga, Sachiko Miura, Tomomi Morishita, Yukihiro Kabeya, Kimihiro Terasawa, Yutaka Suzuki, Yasuyuki Ishii, Shuichi Asakawa, Hiroyoshi Takano, Niji Ohta, Haruko Kuroiwa, Kan Tanaka, Nobuyoshi Shimizu, Sumio Sugano, Naoki Sato, Hisayoshi Nozaki, Naotake Ogasawara, Yuji Kohara, Tsuneyoshi Kuroiwa
Nature 2004 April 8, 428 (6983): 653-7
Small, compact genomes of ultrasmall unicellular algae provide information on the basic and essential genes that support the lives of photosynthetic eukaryotes, including higher plants. Here we report the 16,520,305-base-pair sequence of the 20 chromosomes of the unicellular red alga Cyanidioschyzon merolae 10D as the first complete algal genome. We identified 5,331 genes in total, of which at least 86.3% were expressed. Unique characteristics of this genomic structure include: a lack of introns in all but 26 genes; only three copies of ribosomal DNA units that maintain the nucleolus; and two dynamin genes that are involved only in the division of mitochondria and plastids. The conserved mosaic origin of Calvin cycle enzymes in this red alga and in green plants supports the hypothesis of the existence of single primary plastid endosymbiosis. The lack of a myosin gene, in addition to the unexpressed actin gene, suggests a simpler system of cytokinesis. These results indicate that the C. merolae genome provides a model system with a simple gene composition for studying the origin, evolution and fundamental mechanisms of eukaryotic cells.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"