[The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats]

Ti-juan Cheng, Yu-bin Wang, Li-ping Gao, Yi-fang Sun, Jian Zhang
Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica 2003, 28 (6): 548-50

OBJECTIVE: To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action.

METHOD: Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI).

RESULT: Seed oil of Hippophae rhamnides 0.7 and 0.35 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats.

CONCLUSION: These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.

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