JOURNAL ARTICLE

[The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats]

Ti-juan Cheng, Yu-bin Wang, Li-ping Gao, Yi-fang Sun, Jian Zhang
Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica 2003, 28 (6): 548-50
15015338

OBJECTIVE: To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action.

METHOD: Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI).

RESULT: Seed oil of Hippophae rhamnides 0.7 and 0.35 g.kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats.

CONCLUSION: These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.

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