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Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease.

Joseph F Quinn, Kathleen S Montine, Milar Moore, Jason D Morrow, Jeffrey A Kaye, Thomas J Montine
Journal of Alzheimer's Disease : JAD 2004 Februrary
We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both alpha-tocopherol and vitamin C.

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