RETMEN2A and RETMEN2B oncoproteins are targets of PP1 inhibitor

Italia Bongarzone, Cristiana Carniti, Carla Perego, Piera Mondellini, Marco Alessandro Pierotti
Tumori 2003, 89 (5): 550-2
Medullary thyroid carcinoma (MTC) responds very poorly to chemotherapy. Mutations in the RET gene are critical for MTC pathogenesis. RET therefore represents a rational target for the development of novel MTC therapies. The accumulation of evidence from laboratory studies strongly suggests that PP1 inhibitor is a cytostatic agent for cells expressing RET oncoproteins. PP1 functions as a potent and selective inhibitor of RET oncoprotein phosphorylation, promoting its proteasomal degradation.

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