JOURNAL ARTICLE

Probability effects on the neural correlates of retrieval success: an fMRI study

Jane E Herron, Richard N A Henson, Michael D Rugg
NeuroImage 2004, 21 (1): 302-10
14741668
Event-related fMRI was employed to investigate the influence of the relative probability of old and new test items on the neural correlates of recognition memory. Twelve subjects undertook three study-test cycles, each consisting of an identical study phase in which a series of words was encoded in an incidental task, followed by a test phase in which yes/no recognition judgments were made to a mixture of studied (old) and unstudied (new) words. The ratio of old to new words differed in each test phase, and was either 25:75, 50:50, or 75:25. In lateral inferior and medial parietal cortex, and the posterior cingulate, greater activity was elicited by correctly classified old than new items independently of old:new ratio. By contrast, in other regions, including anterior, dorsolateral, and ventrolateral prefrontal cortex, differences in the activity elicited by old and new items varied according to old:new ratio, demonstrating in some cases a complete crossover interaction. The results suggest that differential activity elicited by old and new test items is likely to support successful recognition in only a subset of the regions identified in previous studies as exhibiting such differences. In other regions, most notably prefrontal cortex, differences in the activity elicited by old and new items appear to reflect processes that are contingent upon, rather than in support of, successful recognition.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
14741668
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"