Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats

Cleide de Sousa Lino, João Paulo Luz Diógenes, Bruno Azevedo Pereira, Rozilaine Aparecida Pelegrine Gomes Faria, Manoel Andrade Neto, Renata Sousa Alves, Maria Goreti Rodrigues de Queiroz, Francisca Cléa Florenço de Sousa, Glauce Socorro Barros Viana
Biological & Pharmaceutical Bulletin 2004, 27 (1): 125-7
The antidiabetic activity of aqueous, ethanolic and hexanic extracts of Bauhinia forficata was investigated in a model of alloxan-induced diabetes in rats. The biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). Extracts were administered daily for 7 d at doses of 200 and 400 mg/kg, p.o., 48 h after alloxan injection (60 mg/kg, i.v.). The alloxan-diabetic rats showed significant reductions in plasma glucose, triglycerides, total cholesterol and HDL-cholesterol after treatment with the extracts and glibenclamide (used as standard) as compared to the diabetic controls. Levels of LDL were not altered. In conclusion, our results showed that the plant extracts when administered by gavage may reduce glucose, triglycerides, total cholesterol and HDL-cholesterol levels. These results suggest the validity of the clinical use of B. forficata in the treatment of diabetes mellitus type II.

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