Accompanying liver cirrhosis as a risk factor for recurrence after resection of solitary hepatocellular carcinoma

Yasutsugu Takada, Masaaki Otsuka, Takeshi Todoroki, Katashi Fukao
Hepato-gastroenterology 2003, 50 (54): 1991-5

BACKGROUND/AIMS: A high recurrence rate after hepatic resection adversely influences the postoperative prognosis of patients with hepatocellular carcinoma. In the present study, long-term results and prognostic factors were evaluated in patients who underwent hepatic resection for solitary hepatocellular carcinoma.

METHODOLOGY: The records of 105 patients who underwent hepatic resection for hepatocellular carcinoma between June 1978 and April 2000 were retrospectively reviewed. In 61 patients with solitary hepatocellular carcinoma who survived the curative operation, the prognostic significance of 11 clinicopathological parameters was investigated by univariate and multivariate analyses.

RESULTS: After curative resection, the cumulative survival rate at 5 years in these 61 patients with solitary hepatocellular carcinoma was significantly better than in 25 patients with multiple hepatocellular carcinomas (44% vs. 25%, p = 0.01). However, even in the solitary group, the cumulative recurrence-free survival rate at 5 years was only 32%; and in 27 (75%) of 36 patients, in whom recurrence was confirmed within 5 years, hepatocellular carcinoma recurred within 2 years. Multivariate analysis disclosed that only accompanying liver cirrhosis was a variable having prognostic significance for overall and recurrence-free survival. A study of other clinicopathological factors, including tumor size, failed to demonstrate any prognostic value.

CONCLUSIONS: The present result suggests that hepatic resection can be indicated in patients with solitary hepatocellular carcinoma, irrespective of its size. Though the postoperative recurrence associated with the underlying cirrhosis is still frequent, long-term survival can be expected if the recurrent tumors are successfully treated by a strategy using multiple modalities.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"