Spontaneous remission of massive solitary eosinophilic granuloma of the femur.

The authors describe two children with a history of pain and limping who showed a solitary extensive diaphyseal lesion of the femur. A needle biopsy confirmed the diagnosis of eosinophilic granuloma. Without any treatment, both patients went into spontaneous total remission after the percutaneous biopsy. At last follow-up (after 4 years), there was no clinical evidence of disease, and a femur x-ray appeared normal. These two cases suggest that until additional biologic parameters of disease behavior are clarified, some patients with eosinophilic granuloma might be grossly overtreated due to misinterpretation of radiographic images.