JOURNAL ARTICLE

Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines

Teresa Krakauer, Marilyn Buckley
Antimicrobial Agents and Chemotherapy 2003, 47 (11): 3630-3
14576133
Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

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