The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells

Daniel J Pennington, Bruno Silva-Santos, John Shires, Efstathios Theodoridis, Christopher Pollitt, Emma L Wise, Robert E Tigelaar, Michael J Owen, Adrian C Hayday
Nature Immunology 2003, 4 (10): 991-8
Although T cell receptor (TCR)gammadelta+ and TCRalphabeta+ cells are commonly viewed as functionally independent, their relatedness and potential interdependence remain enigmatic. Here we have identified a gene profile that distinguishes mouse gammadelta cell populations from conventional alphabeta T cells. However, this profile was also expressed by sets of unconventional alphabeta T cells. Therefore, whereas TCR specificity determines the involvement of a T cell in an immune response, the cell's functional potential, as assessed by gene expression, does not segregate with the TCR. By monitoring the described gene profile, we show that gammadelta T cell development and function in TCRbeta-deficient mice was impaired because of the absence of alphabeta T cell progenitors. Thus, normal gammadelta cell development is dependent on the development of conventional alphabeta T cells.

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