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ADAPTIVE ENZYME SYNTHESIS: ITS INHIBITION AS A POSSIBLE ANALOGUE OF IMMUOLOGICAL TOLERANCE.

Science 1965 July 31
Substrate induction of tryptophan pyrrolase in the liver of rats is inhibited by prior treatment of very young rats with tryptophan. This inhibition seems analogous to immunological tolerance, which can be produced by prior treatment with the antigen. The findings prowide support for an analogy between mechanisms of adaptive enzyme synthesis and those involved in adaptive immunity.

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