Hepatocellular carcinoma associated with arteriohepatic dysplasia in a 4-year-old girl

A N Békássy, S Garwicz, T Wiebe, I Hägerstrand, O A Jensen
Medical and Pediatric Oncology 1992, 20 (1): 78-83
Hepatocellular carcinoma and obliterated hepatic bile duct were found at postmortem examination in a 4-year-old girl with arteriohepatic dysplasia (Alagille's syndrome). AFP level was extremely high. Liver cirrhosis was present on percutaneous needle biopsy 9 months before she succumbed in progressive liver failure. Episodes of repeated gastrointestinal, life-threatening hemorrhages occurred during the last 6 months of her life. Histopathologic findings of the eyes were documented at autopsy.

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