[Plasma haemostatic and fibrinolytic activities and their relationship to levels of serum lipids and apolipoproteins in endogenous hypertriglyceridemic patients].

OBJECTIVE: To investigate the changes of plasma haemostatic and fibrinolytic activities and their relationship to serum lipids and apolipoproteins levels in endogenous hypertriglyceridemic patients.

METHODS: We determined the plasma prothrombin time(PT), activated partial thromplastin time(APTT), activity of tissue-type plasminogen activator(t-PA), activity of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen(Fg) level of 24 endogenous hyper-triglyceridemic patients and 34 healthy controls, and observed their relationship to serum lipids and apolipoproteins.

RESULTS: The PT and APTT of patients with hypertriglyceridemia were obviously shorter than those of control subjects (P < 0.01, P < 0.05); PAI-1 of patients was significant higher than that of control group (P < 0.01); there was no statistically significant difference in t-PAI-1: a between the control subjects and the hypertriglyceridemic patients; the levels of Fg in patients was 27% higher than that in healthy control (P < 0.01). The correlation analysis indicated that PT was significantly associated with the levels of plasma HDL-C (r = 0.445, P < 0.01), and inversely associated with the levels of plasma TG, apoC III, BG and BMI (r = -0.294, -0.320, -0.282, -0.272, P < 0.05); APTT was negatively correlated with serum TG and apoC III levels (r = -0.345, -0.320, P < 0.05); t-PA was negatively correlated with BG levels (r = -0.336, P < 0.01). PAI-1 and Fg levels were strongly correlated with serum TG, apoC II, C III and E levels (r = 0.400, 0.408, 0.497, 0.454, P < 0.01 and r = 0.642, 0.581, 0.673, 0.304, P < 0.01, respectively), and negatively correlated with HDL-C (r = -0.366, -0.524, P < 0.01).

CONCLUSION: Increasing of coagulating activity and decreasing of fibrinolytic activity in hypertriglyceridemic patients were significantly associated with serum lipids and apolipoproteins levels.