Drug-induced myopathies

Bernard Bannwarth
Expert Opinion on Drug Safety 2002, 1 (1): 65-70
Drug-induced muscle disorders represent a broad clinical spectrum, from asymptomatic elevated serum creatine kinase levels to life-threatening myopathies. An increasing number of drugs have been suspected or identified as myotoxic. It would be unrealistic to attempt to list them. In clinical practice, an iatrogenic origin must be discussed in any patient presenting with muscle symptoms in as much as drug-induced myopathies are usually reversible after discontinuation of the offending compound. The clinical and histopathological features depend on the causative agent and individual susceptibility to a given compound. Apart from isolated myalgias, drug-induced myopathies can be divided into five major categories: necrotising myopathies mainly due to lipid-lowering drugs; inflammatory myopathies, including polymyositis (especially associated with thiol compounds) and maphrophagic myofasciitis; mitochondrial myopathies, mainly due to antiretroviral nucleoside analogues; corticosteroid myopathy; and various forms of painless neuromyopathies. In some cases (e.g., statin-induced myopathies), risk factors have been clearly identified and preventive measures have been recommended.

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