We have located links that may give you full text access.
COMPARATIVE STUDY
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Expression of E-cadherin, beta-catenin, CD44s and CD44v6 in gastric adenocarcinoma: relationship with lymph node metastasis.
Anticancer Research 2003 March
BACKGROUND: The aim of this study was to examine the expression of E-cadherin, beta-catenin, CD44s and CD44v6 in gastric adenocarcinoma and to investigate whether these proteins are objective in markers in predicting the lymph node metastasis.
MATERIALS AND METHODS: In 99 cases of gastric adenocarcinoma, the expressions of E-cadherin, beta-catenin, CD44s and CD44v6 were studied by immunohistochemistry.
RESULTS: The expressions of E-cadherin and beta-catenin were significantly associated with histological type, but not with tumor progression and lymph node metastasis. In contrast, the expressions of CD44s and CD44v6 showed significant relationships with lymphovascular invasion, TNM stage, p53 expression, high Ki-67 LIs and lymph node metastasis. Under univariate analysis, the diffuse-type of Lauren classification, CD44s expression, CD44v6 expression and p53 expression were predictive of lymph node metastasis. By multivariate analysis, diffuse-type and p53 expression were independent factors of lymph node metastasis; among the CAMs investigated, only CD44v6 expression was a significant risk factor related to lymph node metastasis in the advanced carcinoma group.
CONCLUSION: Expressions of CD44s and CD44v6 play an important role in tumor progression; especially, CD44v6 expression may be a useful predictor of lymph node metastasis, while the expressions of E-cadherin and beta-catenin complex are more probably related to tumor morphology than to tumor progression.
MATERIALS AND METHODS: In 99 cases of gastric adenocarcinoma, the expressions of E-cadherin, beta-catenin, CD44s and CD44v6 were studied by immunohistochemistry.
RESULTS: The expressions of E-cadherin and beta-catenin were significantly associated with histological type, but not with tumor progression and lymph node metastasis. In contrast, the expressions of CD44s and CD44v6 showed significant relationships with lymphovascular invasion, TNM stage, p53 expression, high Ki-67 LIs and lymph node metastasis. Under univariate analysis, the diffuse-type of Lauren classification, CD44s expression, CD44v6 expression and p53 expression were predictive of lymph node metastasis. By multivariate analysis, diffuse-type and p53 expression were independent factors of lymph node metastasis; among the CAMs investigated, only CD44v6 expression was a significant risk factor related to lymph node metastasis in the advanced carcinoma group.
CONCLUSION: Expressions of CD44s and CD44v6 play an important role in tumor progression; especially, CD44v6 expression may be a useful predictor of lymph node metastasis, while the expressions of E-cadherin and beta-catenin complex are more probably related to tumor morphology than to tumor progression.
Full text links
Trending Papers
A Personalized Approach to the Management of Congestion in Acute Heart Failure.Heart International 2023
Potential Mechanisms of the Protective Effects of the Cardiometabolic Drugs Type-2 Sodium-Glucose Transporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure.International Journal of Molecular Sciences 2024 Februrary 21
The Effect of Albumin Administration in Critically Ill Patients: A Retrospective Single-Center Analysis.Critical Care Medicine 2024 Februrary 8
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app