Characterization of a novel coronavirus associated with severe acute respiratory syndrome

Paul A Rota, M Steven Oberste, Stephan S Monroe, W Allan Nix, Ray Campagnoli, Joseph P Icenogle, Silvia Peñaranda, Bettina Bankamp, Kaija Maher, Min-Hsin Chen, Suxiong Tong, Azaibi Tamin, Luis Lowe, Michael Frace, Joseph L DeRisi, Qi Chen, David Wang, Dean D Erdman, Teresa C T Peret, Cara Burns, Thomas G Ksiazek, Pierre E Rollin, Anthony Sanchez, Stephanie Liffick, Brian Holloway, Josef Limor, Karen McCaustland, Melissa Olsen-Rasmussen, Ron Fouchier, Stephan Günther, Albert D M E Osterhaus, Christian Drosten, Mark A Pallansch, Larry J Anderson, William J Bellini
Science 2003 May 30, 300 (5624): 1394-9
In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"