JOURNAL ARTICLE
REVIEW

[Acute-phase reaction]

Bernard Bonnotte, Nils-Olivier Olsson, Bernard Lorcerie
La Revue du Praticien 2003 March 1, 53 (5): 489-94
12722605
The systemic changes induced by inflammation have been referred as the acute-phase response. The changes in the concentrations of acute-phase proteins are due largely to changes in their production by hepatocytes induced by pro-inflammatory cytokines. Because of its specificity, sensibility and short half-life, C-reactive protein is the most useful indicator among all the acute-phase proteins. The clinical strategy to deal with an acute-phase response is to search the aetiology: infections, neoplasms, auto-immune and allergic diseases. The treatment of an acute-phase response is the treatment of its aetiology.

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