Cervical root repair in adult rats after transection: recovery of forelimb motor function

Ming-Chao Huang, Kuo-Chi Chen, Tien-Yow Chuang, Wen-Chi Chang, Liang-Shong Lee, Wen-Chung Huang, Henrich Cheng
Experimental Neurology 2003, 180 (2): 101-9
Functional recovery was achieved in rats after repairing the transected left sixth and seventh cervical roots. Intercostal nerves were used for reanastomosis between the transected roots and the spinal cord, and acidic fibroblast growth factor with fibrin glue was applied. Experimental rats showed relevant functional recovery of gait and grooming reflexes. Electromyography demonstrated less denervation and more regeneration. Horseradish peroxidase retrograde axonal tracing disclosed a statistically significant increase of motor neuron survival, suggesting that motor neuron survival was significantly correlated with functional recovery. It is our belief that this novel treatment strategy may help patients with similar injuries in the future.

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