We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Fasting and post-glucose load--reference limits for peripheral venous plasma glucose concentration in pregnant women.
Clinical Chemistry and Laboratory Medicine : CCLM 2003 Februrary
Recently both the American Diabetes Organization (ADA) and World Health Organization (WHO) have revised the diagnostic recommendations for gestational diabetes mellitus (GDM), however, they did not not reach agreement on the criteria for diagnosis, the referral criteria for the confirmatory oral glucose tolerance test (OGTT), its standardization, and diagnostic cut-off point. The aims of this study were to investigate if the fasting venous plasma glucose mmol/l (f-vPG) and the 2-hour venous plasma glucose mmol/l (2h-vPG) after a WHO standardized 75 g oral glucose tolerance test (OGTT) in a non-risk group of pregnant women during first and third trimester of pregnancy deviated from that of risk groups, to establish a reference interval for f-vPG and 2h-vPG, and to investigate the predictive role of f-vPG for the 2h-vPG glucose concentration. This is a population-based case-control study where a consecutive number of pregnant women were invited to screening irrespective of their risk factors for GDM. All women filled in a questionnaire of the Danish national screening program on risk factors and had f-vPG and the 2h-vPG measured. By ruling out women with GDM and risk factors, we isolated a non-risk reference class. The In f-vPG parametric 97.5 centile was less than 5% higher during week 32 of pregnancy than during week 20, and therefore these groups were combined. The f-vPG 95% reference interval was from 4.01 mmol/l (95% CI: 3.96 to 4.07 mmol/l) to 5.26 mmol/l (95% CI: 5.19 to 5.34 mmol/l). "The true upper normal limit", the 99.9 centile, was 5.69 mmol/l (95% CI: 5.59 to 5.80 mmol/l). The f-vPG was 0.6 mmol/l lower over the whole range in pregnant women compared to age-matched non-pregnant women. The distribution of 2h-vPG concentrations at week 20 was non-Gaussian and therefore considered non-homogeneous, while it was Gaussian distributed and homogeneous at week 32. The 2h-vPG 95% reference interval of the combined weeks was from 2.80 mmol/l (95% CI: 2.56 to 3.04 mmol/l) to 7.58 mmol/l (95% CI: 7.34 to 7.82 mmol/l), and the upper limit of normal (99.9 centile) was 8.96 mmol/l (95% CI: 8.63 to 9.29 mmol/l). Distributions of f-vPG and 2h-vPG were distinct in our defined risk classes. In individual cases, no systematic correlation was found between the f-vPG concentration at week 20 and week 32. The f-vPG concentrations at any of the weeks did not predict the 2h-vPG level and no single clinical risk factor was decisive for the presence of GDM.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
Perioperative echocardiographic strain analysis: what anesthesiologists should know.Canadian Journal of Anaesthesia 2024 April 11
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app