Lupus-associated toxic epidermal necrolysis: a novel manifestation of lupus?

Rochelle Mandelcorn, Neil H Shear
Journal of the American Academy of Dermatology 2003, 48 (4): 525-9

BACKGROUND: Toxic epidermal necrolysis is an acute mucocutaneous reaction characterized by extensive cutaneous and mucosal sloughing and systemic involvement. It is generally associated with drug ingestion.

OBJECTIVE AND METHODS: We describe 2 patients who developed typical clinical and histopathologic features of toxic epidermal necrolysis with unusual subacute progression, absence of systemic involvement or high-risk drug ingestion, and features of lupus erythematosus.

CONCLUSION: We propose that this constellation of features represents a new entity not previously described. This entity may represent a more severe variant of Rowell's syndrome or, alternatively, a novel manifestation of lupus erythematosus

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