JOURNAL ARTICLE

Bullous SLE: response to methotrexate and relationship with disease activity

G Malcangi, G Brandozzi, M Giangiacomi, M Zampetti, M G Danieli
Lupus 2003, 12 (1): 63-6
12587829
We report on a case of 40-year-old female with systemic lupus erythematosus (SLE) who developed a severe bullous eruption on sun-exposed areas. The bullous manifestation was associated with a flare of lupus serologies, whereas the previous manifestations of the disease were quiescent. Due to prior intolerance to many drugs, she was given oral methotrexate (10 mg/week). The drug administration was followed by a rapid and full resolution of cutaneous lesions. Five months later she developed a class III lupus nephritis. Our case is the first report of efficacy of methotrexate in bullous SLE and rises the question of the relationship between bullous eruption and SLE activity.

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