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Journal Article
Research Support, U.S. Gov't, P.H.S.
Anatomical correlates of dyslexia: frontal and cerebellar findings.
Brain 2003 Februrary
In this study, we examined the neuroanatomy of dyslexic (14 males, four females) and control (19 males, 13 females) children in grades 4-6 from a family genetics study. The dyslexics had specific deficits in word reading relative to the population mean and verbal IQ, but did not have primary language or motor deficits. Measurements of the posterior temporal lobe, inferior frontal gyrus, cerebellum and whole brain were collected from MRI scans. The dyslexics exhibited significantly smaller right anterior lobes of the cerebellum, pars triangularis bilaterally, and brain volume. Measures of the right cerebellar anterior lobe and the left and right pars triangularis correctly classified 72% of the dyslexic subjects (94% of whom had a rapid automatic naming deficit) and 88% of the controls. The cerebellar anterior lobe and pars triangularis made significant contributions to the classification of subjects after controlling for brain volume. Correlational analyses showed that these neuroanatomical measurements were also significantly correlated with reading, spelling and language measures related to dyslexia. Age was not related to any anatomical variable. Results for the dyslexic children from the family genetics study are discussed with reference to dyslexic adults from a prior study, who were ascertained on the basis of a discrepancy between phonological coding and reading comprehension. The volume of the right anterior lobe of the cerebellum distinguished dyslexic from control participants in both studies. The cerebellum is one of the most consistent locations for structural differences between dyslexic and control participants in imaging studies. This study may be the first to show that anomalies in a cerebellar-frontal circuit are associated with rapid automatic naming and the double-deficit subtype of dyslexia.
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