JOURNAL ARTICLE

Celecoxib-related renal papillary necrosis

Laila Akhund, Robert J Quinet, Saliha Ishaq
Archives of Internal Medicine 2003 January 13, 163 (1): 114-5
12523925
Selective cyclooxygenase 2 (COX-2) inhibitors are known to affect renal prostaglandins (epoprostenol and dinoprostone), which are at least in part COX-2 dependent. Consequently, adverse events including hypertension, peripheral edema, hypercalemia, hyponatremia, and acute renal failure have been reported to occur with the new COX-2-specific inhibitors. This case report posits celecoxib as a likely cause of renal papillary necrosis and alerts physicians to the possibility of this additional renal complication with COX-2-specific inhibitors.

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