Ovarian cancer associated with inherited mutations in BRCA1 or BRCA2

Elizabeth Swisher
Current Women's Health Reports 2003, 3 (1): 27-32
Most hereditary ovarian cancers are associated with germline mutations in the BRCA1 or BRCA2 genes. These genes are involved in many vital cellular functions, including DNA damage recognition, DNA repair, and control of transcription. Prophylactic oophorectomy is the most effective method of reducing ovarian cancer risk in women known to carry BRCA1 or BRCA2 mutations. Women with BRCA1-associated ovarian cancers seem to have a somewhat better survival than women with sporadic ovarian cancer. Loss of BRCA1 function may impact response to chemotherapy via effects on DNA damage response. Research priorities include designing functional tests for BRCA1 and BRCA2, understanding the impact of BRCA1 and BRCA2 mutations on response to specific cancer therapies, and development of innovative cancer prevention strategies in women with BRCA1 and BRCA2 mutations.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"