Chronic metoclopramide therapy for diabetic gastroparesis.

OBJECTIVE: To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.

DATA SOURCES: Medical literature was accessed through MEDLINE (1965 to October 2002) and PubMed (1965 to October 2002). Key search terms included metoclopramide; diabetic gastroparesis; and dyskinesia, drug induced.

DATA SYNTHESIS: Metoclopramide is often used for diabetic gastroparesis, despite the risk of tardive dyskinesia. Published information is limited regarding long-term efficacy and toxicity of metoclopramide. The literature was assessed concerning these topics.

CONCLUSIONS: Limited data do not provide sufficient evidence to conclude whether metoclopramide is efficacious for chronic use. Routine monitoring may mitigate the risk associated with metoclopramide therapy.