Acute renal failure after local gentamicin treatment in an infected total knee arthroplasty

Tom M van Raaij, Loes E Visser, Arnold G Vulto, Jan A N Verhaar
Journal of Arthroplasty 2002, 17 (7): 948-50
Local gentamicin treatment in revision surgery for infected hip and knee prostheses is well established. It is a safe and effective method compared with the systemic use of aminoglycosides. Although nephrotoxic side effects are uncommon, we report a case of acute renal failure after 2-stage revision treatment of an infected knee prosthesis with gentamicin-impregnated beads and block spacers. The combined use of beads and a cement block spacer, both gentamicin impregnated, may have induced this severe complication. Use of this procedure in elderly patients warrants careful follow-up of renal function.

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