Intracranial hemorrhage in neuro-Behçet's syndrome.

OBJECTIVE: Most cerebrovascular disturbances in Behçet's syndrome are occlusive in nature, while hemorrhage is rare. In this paper, we report three cases of neuro-Behçet's syndrome presenting with intracerebral hemorrhaging, and discuss the possible causes as they relate to cyclosporine treatment.

PATIENTS: Three cases of neuro-Behçet's syndrome presented with intracranial hemorrhage. One patient had been taking cyclosporine, and the other two patients had never taking cyclosporine.

RESULTS: Together with previous reports, these cases suggest that there are two types of intracranial hemorrhage in neuro-Behçet's syndrome. One type occurs in the center of a lesion and during the acute phase of the disease, while the other occurs in the peripheral lesion and during the subacute phase.

CONCLUSIONS: It appears that the intracranial hemorrhages in neuro-Behçet's syndrome can be divided into two groups. It is possible that the vascular pathologies caused by Behçet's syndrome and by cyclosporine conspire to induce CNS hemorrhaging in some cases.