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CLINICAL TRIAL
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RANDOMIZED CONTROLLED TRIAL
RESEARCH SUPPORT, NON-U.S. GOV'T
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A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis.

Paul N Newton, Le Hung Thai, Nguyen Quoc Tip, Jennifer M Short, Wirongrong Chierakul, Adul Rajanuwong, Punnee Pitisuttithum, Sanchai Chasombat, Benjaluck Phonrat, Wirach Maek-A-Nantawat, Reungsilp Teaunadi, David G Lalloo, Nicholas J White
Clinical Infectious Diseases 2002 September 16
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.

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